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Methotrexate Therapy Side Effects

Methotrexate (MTX) is one of the most widely used medications for treating rheumatoid arthritis (RA), and has been proven to work well. MTX decreases the body's auto-immune response, which results in less inflammation and pain.

Although MTX is effective, it can also decrease the body's much-needed supply of folate. Folate helps the body produce red blood cells, supports adrenal function, and maintains a healthy nervous system. When your body is low in folate, you may experience nausea, fatigue, flu-like symptoms, stomach pain, mouth sores, hair loss, elevated liver enzyme levels, and a low number of blood cells (leukopenia and anemia).

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Folic Acid & MTHFR Genetic Defect

According to the CDC, nearly half of the population has a genetic deficiency that doesn't allow their body to convert folic acid to active folate, eliminating any benefit of folic acid supplements. Further complicating the problem, MTX also inhibits folic acid conversion to active folate.

When patients can no longer tolerate MTX, physicians prescribe biologics, which are extremely expensive and add to the overall cost of care.

Living Better With RA

Rheumate Safely Counteracts Methotrexate Side Effects

Rheumate is a prescription medical food that counteracts the side effects and replenishes folate depleted by methotrexate - the most commonly prescribed medication used to manage rheumatoid arthritis.

Works by delivering a biocompatible form of folate (L-5-methyltetrahydrofolate) that doesn't need to be converted by the body; unlike traditional folic acid.

Contains vitamin B12 and curcumin - an antioxidant powerhouse that combats oxidative stress.

Download retail pharmacy Pay-No-More-Than-$99 Coupon for your patients. Medicare patients eligible, see coupon for details.

Only $35/month with Primus Care Direct Prescription Fax Form for direct pharmacy services & guaranteed lowest price (learn more).

See full Prescribing Information for Rheumate.

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Primus Pharmaceuticals

Primus Pharmaceuticals offers first-in-class prescription medical foods available to patients under physician supervision; its products work on the underlying cause of disease, rather than masking symptoms.

Medical foods are medicines regulated by the U.S. Food and Drug Administration (FDA) as a distinct category from drugs or dietary supplements; are intended for the dietary (metabolic) management of a disease, and their effectiveness must be proven by sound laboratory and clinical science.

Unlike drugs, prescription medical foods generally do not cause severe adverse events or dangerous drug-on-drug interactions. Primus Pharmaceuticals' medical foods have earned the highest standard of safety at the FDA: the ingredients have received GRAS affirmation (“generally recognized as safe”).

Rheumate FAQ

Frequently Asked Questions:

What are the key ingredients in Rheumate?

Rheumate is a mixture of the active folate L-5-methyltetrahydrofolate (1mg), curcumin (curcuminoid turmerone complex, 500mg) a powerful antioxidant that addresses methotrexate induced oxidative stress, and vitamin B-12 (1mg) to avoid masking borderline B-12 deficiency from taking folate supplements.
full list of ingredients

How is Rheumate prescribed?

Take one capsule by mouth once or twice daily as directed by a physician. Rheumate is safe to be taken with or without food.
full prescribing information

When should Rheumate start working?

Rheumate may take up to 2 to 4 weeks of use for maximum effect.
full mechanism of action

Does Rheumate cause side effects?

The most common side effects are mild diarrhea, nausea, and upset stomach. These are often mild and usually does not mean a patient needs to discontinue use.
full safety information

Who should take Rheumate?

Rheumatoid arthritis patients suffering the numerous side effects of methotrexate therapy (e.g. fatigue, nausea, mouth sores, hair loss, liver toxicity).
full prescribing information

How much does Rheumate cost?

We guarantee the lowest possible price with Primus Care Direct; complete with free shipping. Pay no more than $35 for 30-day supply. Just $29 per month when purchased 90 days at a time.
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Healthcare Professionals: Help your patients discover Rheumate; safely counteract side effects from methotrexate.


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