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Chronic Venous Disease (CVD)

As many as 35 percent of U.S. adults suffer from the manifestations of CVD, which can limit daily activities and significantly impact quality of life. Blood clots, obesity, smoking, muscle weakness, leg injury, and sitting or standing for a long time without moving can cause vein damage.

CVD occurs when the vein walls holding the valves become damaged and can't effectively return blood from the legs to the heart. The blood pools, absorbs acidic metabolic waste products, and makes the problem worse. CVD is a chronic, progressive disease that manifests as a variety of health issues such as leg edema (fluid retention), varicose veins, leg ulcers, stasis dermatitis (skin disease leading to ulcers), hemorrhoids.

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Treatment Options

Millions of people suffer silently with uncomfortable, embarrassing, and potentially debilitating manifestations caused by chronic venous disease (CVD). The vast majority of physicians and patients are only aware of traditional treatments that do not manage the underlying disease - including topical creams, compression socks, or surgical vein procedures.

Don't Suffer In Vein

Vasculera Manages The Body's Microcirculatory Balance

Vasculera is a prescription medical food containing purified diosmin, a flavonoid that restores the body's microcirculatory balance; shown safe and effective in managing CVD in more than 50 published and peer-reviewed clinical studies.

Diosmin has more than three decades of demonstrated clinical results worldwide, including resolving ulcers and reducing ankle circumference.

Now available in the U.S. with Vasculera; delivering highly-purified diosmiplex in an easy-to-swallow tablet.

Download retail pharmacy Pay-No-More-Than-$99 Coupon for your patients. Medicare patients eligible, see coupon for details.

Only $49/month with Primus Care Direct Prescription Fax Form for direct pharmacy services & guaranteed lowest price (learn more).

See full Prescribing Information for Vasculera.

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Primus Pharmaceuticals

Primus Pharmaceuticals offers first-in-class prescription medical foods available to patients under physician supervision; its products work on the underlying cause of disease.

Medical foods are medicines regulated by the U.S. Food and Drug Administration (FDA) as a distinct category from drugs or dietary supplements; are intended for the dietary (metabolic) management of a disease, and their effectiveness must be proven by sound laboratory and clinical science.

Unlike drugs, prescription medical foods generally do not cause severe adverse events or dangerous drug-on-drug interactions. Primus Pharmaceuticals' medical foods have earned the highest standard of safety at the FDA: the ingredients have received GRAS affirmation (“generally recognized as safe”).

Vasculera FAQ

Frequently Asked Questions:

What are the key ingredients in Vasculera?

Diosmiplex is a combination of purified diosmin (600mg) and alka4-complex (30mg). Diosmin is a flavonoid found in citrus; used in Europe as a prescription product for over 30 years. Alka4-complex is an antacid.
full list of ingredients

How is Vasculera prescribed?

For managing CVD, take one tablet per day. For hemorrhoid flares, take one tablet three times a day for four days. Then, take one tablet twice daily for nine days, or as directed by a physician. To manage chronic hemorrhoidal disease, take one tablet daily.
full prescribing information

When should Vasculera start working?

Some patients experience an effect on leg heaviness or edema within one week. Depending on severity, some patients do not see differences in skin or vein appearance for four to eight weeks. For venous ulcers, patients may see results after several months. For hemorrhoids, patients may see results within days.

Does Vasculera cause side effects?

Commonly reported side effects of diosmin include gastrointestinal disturbances and headaches. These side effects were generally mild, and patients didn't stop using the product. No serious adverse events have been reported in any study of products similar to Vasculera.
full safety information

Who should take Vasculera?

Patients suffering from the manefistations of chronic venous disease (CVD); especially those dissatisfied with traditional treatments which do not manage the underlying disease (e.g. topical creams, compression socks, vein procedures).
full prescribing information

How much does Vasculera cost?

We guarantee the lowest possible price with Primus Care Direct; complete with free shipping. Pay no more than $49 for 30-day supply. Just $45 per month when purchased 90 days at a time.
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Healthcare Professionals: Help your patients discover Vasculera; the first oral therapy for chronic venous disease.


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